An Improved Humanized Mouse Model for Excisional Wound Healing Using Double Transgenic Mice
نویسندگان
چکیده
منابع مشابه
Low-level light stimulates excisional wound healing in mice.
BACKGROUND Low levels of laser or non-coherent light, termed low-level light therapy (LLLT) have been reported to accelerate some phases of wound healing, but its clinical use remains controversial. METHODS A full thickness dorsal excisional wound in mice was treated with a single exposure to light of various wavelengths and fluences 30 minutes after wounding. Wound areas were measured until ...
متن کاملAn in vivo model of wound healing in genetically modified skin-humanized mice.
Cutaneous wound-healing disorders are a major health problem that requires the development of innovative treatments. Whithin this context, the search for reliable human wound-healing models that allow us to address both mechanistic and therapeutic matters is warranted. In this study, we have developed a novel invivo wound-healing model in a genetically modified human context. Our model is based...
متن کاملCorrection: Aberrant Wound Healing in an Epidermal Interleukin-4 Transgenic Mouse Model of Atopic Dermatitis.
In Fig 1, " Wound healing is delayed in the epidermis of IL-4 Tg mice, " panel B appears incorrectly. Please see the corrected Fig 1 below. access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
متن کاملAberrant Wound Healing in an Epidermal Interleukin-4 Transgenic Mouse Model of Atopic Dermatitis
Wound healing in a pre-existing Th2-dominated skin milieu was assessed by using an epidermal specific interleukin-4 (IL-4) transgenic (Tg) mouse model, which develops a pruritic inflammatory skin condition resembling human atopic dermatitis. Our results demonstrated that IL-4 Tg mice had delayed wound closure and re-epithelialization even though these mice exhibited higher degrees of epithelial...
متن کاملHumanized TCR Transgenic Mice
Amino acid residues 111–129 represent an immunodominant epitope of myelin basic protein (MBP) in humans with human leukocyte antigen (HLA)-DRB1 * 0401 allele(s). The MBP 111– 129–specific T cell clone MS2-3C8 was repeatedly isolated from a patient with multiple sclerosis (MS), suggesting an involvement of MS2-3C8 T cells in the pathogenesis. To address the pathogenic potential of the MS2-3C8 T ...
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ژورنال
عنوان ژورنال: Advances in Wound Care
سال: 2018
ISSN: 2162-1918,2162-1934
DOI: 10.1089/wound.2017.0772